September 20, 2010 at 2:59 am #2927
Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori: A Clinical Trial
Giovanni Cammarota, Giovanna Branca, Fausta Ardito, Maurizio Sanguinetti, Gianluca Ianiro, Rossella Cianci, Riccardo Torelli, Giovanna Masala, Antonio Gasbarrini, Giovanni Fadda, Raffaele Landolfi, Giovanni Gasbarrini
published online 17 May 2010.
Background & Aims
. This constitutes protection from antimicrobial agents. We assessed the role of a pretreatment with n-acetylcysteine in destroying biofilm and overcoming H pylori antibiotic resistance.
In an open-label, randomized controlled trial, 40 subjects with a history of at least 4 H pylori eradication failures were evaluated for biofilm presence, antibiotic susceptibility, and H pylori genotypes. Subjects were assigned randomly to receive (group A) or not (group B) n-acetylcysteine before a culture-guided antibiotic regimen. The primary end point was the H pylori eradication rate as assessed by 13C-labeled urea breath testing.
H pylori was eradicated in 13 of 20 (both per-protocol and intention-to-treat analyses, 65%; 95% confidence interval, 44%86%) group A participants and 4 of 20 (both per-protocol and intention-to-treat analyses, 20%; 95% confidence interval, 3%37%) group B participants (P < .01). Biofilms persisted only in unsuccessfully treated participants. H pylori genotypes did not influence treatment outcome. Conclusions N-acetylcysteine pretreatment before a culture-guided antibiotic regimen is effective in overcoming H pylori antibiotic resistance. Funding The study was funded by the Italian Ministry for University, Scientific, and Technological Research.
May 24, 2011 at 3:30 am #3455
Stomach Ulcer Bacteria May Contribute To Development Of Parkinson’s Disease
Article Date: 23 May 2011
The stomach bacteria responsible for ulcers could also play a role in the development of Parkinson’s disease according to research presented at the 111th General Meeting of the American Society for Microbiology.
May 24, 2011 at 11:02 pm #2928
This was sent to me by a friend (thanks Craig).
The Role of Helicobacter Pylori in Pathogenesis of Upper Respiratory System Diseases
Helicobacter pylori (H. Pylori) is one of the frequently encountered micro-organisms in the aerodigestive tract. Although infections caused by H. Pylori are this common, the exact mode of transmission has not been fully understood yet. Oraloral, fecaloral and gastrointestinaloral routes are the possible modes of transmission. This infection is usually acquired in childhood and may persist for the whole life of the patient.
However, about 80% of the infected humans are asymptomatic. Human stomach was considered to be the only reservoir of H. Pylori until bacteria were discovered in human dental plaque, in oral lesions, in saliva, in tonsil and adenoid tissue. It is suggested that H. Pylori enters the nasopharyngeal cavity by gastroesophageal reflux and colonize in the dental plaques, adenoid tissues and tonsils. From these localizations, the bacteria ascend to the middle ear and to the paranasal sinuses directly or by the reflux again and may trigger some diseases, including otitis, sinusitis, phyrangitis, laryngitis and glossitis. But still, the exact mechanism remains unclear.
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