Reply To: Breast Milk Confers Immunity – Gastrointestinal Mucosa

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    For healthy guts, breast milk beats formula
    Posted By On August 28, 2012

    DUKE (US) — Breast milk, but not infant formula, fosters growth of healthy bacteria in a baby’s intestinal tract, research shows.
    This unique property may make mother’s milk better than infant formula in protecting infants from infections and illnesses, according to a study published in the journal [SUP][1][/SUP].

    “This study is the first we know of that examines the effects of infant nutrition on the way that bacteria grow, providing insight to the mechanisms underlying the benefits of breast feeding over formula feeding for newborns,” says William Parker, associate professor of surgery at Duke University and senior author of the study.

    “Only breast milk appears to promote a healthy colonization of beneficial biofilms, and these insights suggest there may be potential approaches for developing substitutes that more closely mimic those benefits in cases where breast milk cannot be provided,” says Parker.

    Straight from the Source

    Earlier studies have shown that breast milk lowers the incidence of diarrhea, influenza, and respiratory infections during infancy, while protecting against the later development of allergies, type 1 diabetes, multiple sclerosis, and other illnesses.

    As scientists have learned more about the role intestinal flora plays in health, they have gained appreciation for how an infant’s early diet can affect this beneficial microbial universe.

    In their study, the Duke researchers grew bacteria in samples of infant formulas, cow’s milk, and breast milk. For the infant formula, the researchers used three brands each of popular milk- and soy-based products, and they purchased whole milk from the grocery store.
    Breast milk was donated and processed to separate different components, including proteins, fats, and carbohydrates. They also tested a purified form of an antibody called secretory immunoglobulin A (SIgA), which is abundant in breast milk and helps establish an infant’s immune system.

    The infant formulas, the milk products and the SIgA were incubated with two strains of E. coli bacteria—necessary early inhabitants of the gut that are helpful cousins to the dangerous organisms associated with food poisoning.

    Within minutes, the bacteria began multiplying in all of the specimens, but there was an immediate difference in the way the bacteria grew. In the breast milk, bacteria stuck together to form biofilms—thin, adherent layers of bacteria that serve as a shield against pathogens and infections.

    Bacteria in the infant formula and cow’s milk proliferated wildly, but it grew as individual organisms that did not aggregate to form a protective barrier. The bacteria in SIgA had mixed results, suggesting that this antibody by itself isn’t enough to trigger the beneficial biofilm formation.

    “Knowing how breast milk conveys its benefits could help in the development of infant formulas that better mimic nature,” Parker says. “This could have a long-lasting effect on the health of infants who, for many reasons, may not get mother’s milk.”

    Additional studies should explore why human whey has the clumping effect on the bacteria, and whether it has a similar effect on strains of bacteria other than E. coli, notes Parker.

    “This study adds even more weight to an already large body of evidence that breast milk is the most nutritious way to feed a baby whenever possible,” says Gabriela M. Maradiaga Panayotti, M.D., co-director of the newborn nursery for Duke Children’s and Duke Primary Care. “We know that babies who receive breast milk have better outcomes in many ways, and mothers who breast feed also have improved health outcomes, including decreased risks of cancer. Whenever possible, promoting breast feeding is the absolute best option for mom and baby.”

    The study was supported in part by the Fannie E. Rippel Foundation and the Howard Hughes Medical Institute.

    Human Whey Promotes Sessile Bacterial Growth, Whereas Alternative Sources of Infant Nutrition Promote Planktonic Growth

    Duke University [SUP][2][/SUP]

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