Effects of photodynamic therapy on periopathogens

The Silent Role of Biofilms in Chronic Disease Forums Biofilm Community The DENT Connection Effects of photodynamic therapy on periopathogens

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        In October of 2010, I interviewed executives from Ondine Biomedical, a company that has deep expertise in photodisinfection, which is effective in treating and eradicating localized (accessible) bacterial biofilms. I’ll be sharing more on this cool technology, including videos, next month.

        PDT is already approved and in use in Canada for dental treatments. In the meantime, here’s a related article originating from Italy.

        Effects of toluidine blue-mediated photodynamic therapy on periopathogens and periodontal biofilm: in vitro evaluation.

        Nastri L, Donnarumma G, Porzio C, De Gregorio V, Tufano MA, Caruso F, Mazza C, Serpico R.

        Department of Stomatologic Orthodontic and Surgical Sciences, Second University of Naples, Naples, Italy.

        Photodynamic therapy (PDT) is a selective modality of killing targeted cells, mostly known for its application in neoplasms. PDT can be considered to be an alternative method for the elimination of periodontal bacteria from the pocket without harms for the resident tissues.

        Therefore, PDT may replace systemic antibiotics and enhance the effect of mechanical treatments of periodontal defects. This effort focused on the in vitro sensitization of periopathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia ) Toluidine Blue mediated and on the use of a Diode laser emitting source.

        The objective of this research was to evaluate the bactericidal in vitro effect of laser diodes 830 nm (as the light source) after photosensitization with Toluidine Blue (TBO) on the following periopathogenic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia.

        After evaluating the effect on the single bacterial strain, the ability of Diode Laser to disrupt the structure of biofilms produced by A. actinomycetemcomitans after photosensitization with TBO was also analyzed. The study suggests that the association of TBO and diode laser light 830 nm is effective for the killing of bacteria strains and determines the photoinactivation of Aggregatibacter biofilms.

        In summary, photodynamic therapy has effectively shown its capabilities and, therefore, it can be considered a valid alternative approach to antimicrobial therapy of periodontitis.

        Source: PubMed

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