Fighting Bacterial & Fungal Biofilms with Coriander – Cilantro

The Silent Role of Biofilms in Chronic Disease Forums Biofilm Community The DENT Connection Fighting Bacterial & Fungal Biofilms with Coriander – Cilantro

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        This article appeared in today’s news. Coriander and cilantro are basically the same plant; seeds are referred to as coriander, the leaves as cilantro. See the second article I dug up for reference.

        Note that that the active ingredients seem to be effective against both the planktonic and biofilm forms of bacteria – as well as candida albicans. I don’t know if we can conclude that it is effective for treating biofilms that are highly polymicrobial – that may be a stretch!

        Fighting Food Poisoning And Drug-Resistant Infections With Coriander Oil
        24 Aug 2011

        Coriander oil has been shown to be toxic to a broad range of harmful bacteria. Its use in foods and in clinical agents could prevent food-borne illnesses and even treat antibiotic-resistant infections, according to the authors of a study published in the Journal of Medical Microbiology.

        The researchers from the University of Beira Interior in Portugal tested coriander oil against 12 bacterial strains, including Escherichia coli, Salmonella enterica, Bacillus cereus and meticillin-resistant Staphylococcus aureus (MRSA). Of the tested strains, all showed reduced growth, and most were killed, by solutions containing 1.6% coriander oil or less.

        Coriander is an aromatic plant widely used in Mediterranean cuisine. Coriander oil is one of the 20 most-used essential oils in the world and is already used as a food additive. Coriander oil is produced from the seeds of the coriander plant and numerous health benefits have been associated with using this herb over the centuries. These include pain relief, ease of cramps and convulsions, cure of nausea, aid of digestion and treatment of fungal infections.

        This study not only shows that coriander oil also has an antibacterial effect, but provides an explanation for how it works, which was not previously understood. “The results indicate that coriander oil damages the membrane surrounding the bacterial cell. This disrupts the barrier between the cell and its environment and inhibits essential processes including respiration, which ultimately leads to death of the bacterial cell,” explained Dr Fernanda Domingues who led the study.

        The researchers suggest that coriander oil could have important applications in the food and medical industries. “In developed countries, up to 30% of the population suffers from food-borne illness each year. This research encourages the design of new food additives containing coriander oil that would combat food-borne pathogens and prevent bacterial spoilage,” said Dr Domingues. “Coriander oil could also become a natural alternative to common antibiotics. We envisage the use of coriander in clinical drugs in the form of lotions, mouth rinses and even pills; to fight multidrug-resistant bacterial infections that otherwise could not be treated. This would significantly improve people’s quality of life.”
        Article URL: Fighting Food Poisoning And Drug-Resistant Infections With Coriander Oil

        Evid Based Complement Alternat Med. 2011; 2011: 985832.
        Published online 2011 May 21. doi: 10.1155/2011/985832
        PMCID: PMC3108195
        Copyright© 2011 V. F. Furletti et al.

        Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation

        V. F. Furletti,1, 2* I. P. Teixeira,1, 2 G. Obando-Pereda,1, 2 R. C. Mardegan,1, 2 A. Sartoratto,2 G. M. Figueira,2 R. M. T. Duarte,2 V. L. G. Rehder,2 M. C. T. Duarte,2 and J. F. Höfling1
        1Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas-UNICAMP, 13414-903 Piracicaba, SP, Brazil
        2Research Center for Chemistry, Biology and Agriculture, University of Campinas-UNICAMP, P.O. Box 6171, 13083-970 Campinas, SP, Brazil
        *V. F. Furletti: Email:
        Received February 10, 2011; Accepted March 17, 2011.


        The efficacy of extracts and essential oils from Allium tuberosum, Coriandrum sativum, Cymbopogon martini, Cymbopogon winterianus, and Santolina chamaecyparissus was evaluated against Candida spp. isolates from the oral cavity of patients with periodontal disease. The most active oil was fractionated and tested against C. albicans biofilm formation. The oils were obtained by water-distillation and the extracts were prepared with macerated dried plant material.

        The Minimal Inhibitory Concentration—MIC was determined by the microdilution method. Chemical characterization of oil constituents was performed using Gas Chromatography and Mass Spectrometry (GC-MS). C. sativum activity oil upon cell and biofilm morphology was evaluated by Scanning Electron Microscopy (SEM). The best activities against planktonic Candida spp. were observed for the essential oil and the grouped F8–10 fractions from C. sativum.

        The crude oil also affected the biofilm formation in C. albicans causing a decrease in the biofilm growth. Chemical analysis of the F8–10 fractions detected as major active compounds, 2-hexen-1-ol, 3-hexen-1-ol and cyclodecane. Standards of these compounds tested grouped provided a stronger activity than the oil suggesting a synergistic action from the major oil constituents. The activity of C. sativum oil demonstrates its potential for a new natural antifungal formulation.

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