Numerous microbial species in oral biofilms: how could antibacterials be effective?

The Silent Role of Biofilms in Chronic Disease Forums Biofilm Community The DENT Connection Numerous microbial species in oral biofilms: how could antibacterials be effective?

This topic contains 0 replies, has 1 voice, and was last updated by  Harrison 6 years, 10 months ago.

  • Author
    Posts
  • #3240 Score: 0

    Harrison
    Keymaster
      2 pts

      Adv Dent Res. 2012 Sep;24(2):108-11. doi: 10.1177/0022034512450028.
      The numerous microbial species in oral biofilms: how could antibacterial therapy be effective?

      &cauthor=true&cauthor_uid=22899691″]ten Cate JM, &cauthor=true&cauthor_uid=22899691″]Zaura E.
      Source

      Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands. j.t.cate( at ) acta.nl

      Abstract

      Hundreds of bacterial species inhabit the oral cavity. Many of these have never been cultivated and can be assessed only with DNA-based techniques. This new understanding has changed the paradigm of the etiology of oral disease from that associated with ‘traditional pathogens’ as being primarily responsible for all diseases. Increasingly, associations between oral bacteria and systemic diseases are being reported. The emergence of antibiotic resistance is alarming and calls for in-depth studies of biofilms, bacterial physiology, and a body-wide approach to infectious diseases. We propose that the borderline between commensal bacteria and pathogens is no longer discrete. In a field of science where so many of the established paradigms are being undermined, a thorough analysis of threats and opportunities is required. This article addresses some of the questions that can be raised and serves to identify research opportunities and needs to leverage the prevention of oral diseases through novel antimicrobial strategies.

      PMID: 22899691 [PubMed – in process]

    You must be logged in to reply to this topic.