Oral Biofilm Architecture on Natural Teeth

The Silent Role of Biofilms in Chronic Disease Forums Biofilm Community The DENT Connection Oral Biofilm Architecture on Natural Teeth

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        A “dated” article, but this is news to many. Including medical professionals.


        Periodontitis and caries are infectious diseases of the oral cavity in which oral biofilms play a causative role. Moreover, oral
        biofilms are widely studied as model systems for bacterial adhesion, biofilm development, and biofilm resistance to
        antibiotics, due to their widespread presence and accessibility. Despite descriptions of initial plaque formation on the tooth
        surface, studies on mature plaque and plaque structure below the gum are limited to landmark studies from the 1970s,
        without appreciating the breadth of microbial diversity in the plaque. We used fluorescent in situ hybridization to localize in
        vivo the most abundant species from different phyla and species associated with periodontitis on seven embedded teeth
        obtained from four different subjects.

        The data showed convincingly the dominance of Actinomyces sp., Tannerella forsythia, Fusobacterium nucleatum, Spirochaetes, and Synergistetes in subgingival plaque. The latter proved to be new with a possibly important role in host-pathogen interaction due to its localization in close proximity to immune cells. The present study identified for the first time in vivo that Lactobacillus sp. are the central cells of bacterial aggregates in subgingival plaque, and that Streptococcus sp. and the yeast Candida albicans form corncob structures in supragingival plaque.

        Finally, periodontal pathogens colonize already formed biofilms and form microcolonies therein. These in vivo observations on oral
        biofilms provide a clear vision on biofilm architecture and the spatial distribution of predominant species.


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