Treatment for Mare Endometritis – Removing Biofilm with "buffered chelating agent"

The Silent Role of Biofilms in Chronic Disease Forums Biofilm Community The Vets Corner Treatment for Mare Endometritis – Removing Biofilm with "buffered chelating agent"

Viewing 0 reply threads
  • Author
    • #3048 Score: 0
        2 pts

        For the record, humans have the same problems…very sad and complicated issues that do affect all of us.

        Time to start working together. For example, what is a third-generation buffered chelating agent?

        New Treatment for Mare Endometritis Examined (AAEP 2011)

        by: Stacey Oke, DVM, MSc
        March 10 2012, Article # 19712

        We’d all like to think that a mare’s womb is a warm, dark, nurturing environment perfect for transforming a small fertilized egg into a healthy foal in 340 days.

        According to equine reproductive specialists, however, uteri can be lined with bacterial “biofilm” containing millions of antibiotic-resistant bacteria in a glutinous, jellylike substance that in some cases can prevent mares from conceiving, much less carrying a foal to term.

        One of these specialists presented an alternative to traditional antibiotics for treating endometritis–or inflammation of the uterine lining–at the 2011 American Association of Equine Practitioners convention, held Nov. 18-22 in San Antonio, Texas. Endometritis can occur post- breeding in reproductively normal mares or those with structural abnormalities of their reproductive tracts that allow bacteria to enter the uterus.

        In either case endometritis is an important cause of infertility in mares. Veterinarians usually treat it with antibiotics and by flushing the uterus, but in some mares this approach may not be sufficient to resolve the inflammation.

        “The bacteria in the biofilm can be up to 500 times more resistant to antibiotics than the same type of bacteria grown in cultures in a lab, and many are also resistant to common antibiotics used in practice. Equine veterinarians therefore need to consider the use of ‘alternative’ methods to treat endometritis in mares rather than relying solely on traditional antibiotics to improve pregnancy rates and treat infertility,” said Sara Lyle, DVM, PhD, Dipl. ACT, assistant professor of theriogenology in the Department of Veterinary Clinical Sciences at Louisiana State University’s School of Veterinary Medicine.

        She explained that one adjunctive therapy for treating endometritis is to wash the uterus with a special “solution” called a buffered chelating agent.

        “A third-generation buffered chelating agent either with or without antibiotics removes ions from the cell walls of bacteria, reducing the integrity of the cell wall,” Lyle explained. “The exudate produced by the disrupted bacteria and biofilm is subsequently removed and the mare can be bred.”

        Veterinarians can prepare buffered chelators in-house using standard laboratory equipment, or they are commercially available with and without traditional antibiotics.

    Viewing 0 reply threads
    • You must be logged in to reply to this topic.